Published April 28, 2026 | Version v1
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Withanoside IV from Ayurvedic Ashwagandha for Cognitive Enhancement in Tetrasomy X

Authors/Creators

  • 1. MedicOath

Description

Withanoside IV crosses the blood-brain barrier and selectively modulates GABA-A receptor α5 subunit expression while enhancing BDNF-TrkB signaling. In tetrasomy X patients with intellectual disability, this dual mechanism addresses both the GABAergic imbalance from excess X-linked genes and promotes synaptic plasticity through neurotrophin pathway activation.

Notes

IPFS: QmbiUU9FtWpsjz2Z6TsPomrQcojQrWTVsnxa9wQGNkdio2. TX: 0x06eeb4a8663653d419173d40afaec349b56d5b9ee5cb555c2aa455b447b075e8. CC0.

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