Combination Albendazole-Praziquantel for Enhanced Guinea Worm Killing

Albendazole binds to β-tubulin in nematode microtubules causing cytoskeletal disruption, while praziquantel increases calcium permeability in parasite tegument through voltage-gated calcium channels. This dual mechanism combination targets both structural integrity and membrane function, potentially overcoming resistance mechanisms and achieving rapid worm death.