Published April 28, 2026 | Version v1
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Imatinib Repurposing for ACVR1 Downstream Signaling Inhibition

Authors/Creators

  • 1. MedicOath

Description

Imatinib mesylate inhibits multiple tyrosine kinases including PDGFR and c-Kit, which are involved in BMP/TGF-β signaling cascades downstream of mutant ACVR1. By blocking these kinases, imatinib may reduce the aberrant osteochondrogenic differentiation and heterotopic ossification characteristic of FOP.

Notes

IPFS: QmQp88cmTnfSNBeTvggvrqUSDn52KZcMXnUUUG6GwoJWNV. TX: 0x5d6e87921cd14d0ed369673eb4b9420a0b8f22cebd7cb561052d47a78accde68. CC0.

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