Published April 28, 2026 | Version v1
Preprint Open

Curcuma longa Ar-Turmerone for Blood-Brain Barrier 2-HG Transport

Authors/Creators

  • 1. MedicOath

Description

Ar-turmerone from turmeric essential oil modulates organic anion transporters OAT1 and OAT3 to enhance 2-hydroxyglutarate efflux from brain tissue while simultaneously inhibiting monocarboxylate transporter-mediated re-uptake. This creates a favorable gradient for 2-HG clearance from the CNS compartment.

Notes

IPFS: QmUAyeaysiEzHSm65V74SaZ8HcBzyRULUaovzZxy8BMfeP. TX: 0x627645949ebcdfd015e768a2d486325cd30ac37e69c775d06d77f14ef2cec138. CC0.

Files

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