Published April 28, 2026
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Withanoside VI from Ayurveda for Opsin Stabilization via HSP90 Modulation
Description
Withanoside VI from Ashwagandha (Withania somnifera) acts as an HSP90 co-chaperone modulator, stabilizing misfolded opsin proteins in blue cone monochromats. By enhancing the folding capacity of the endoplasmic reticulum through HSP90β upregulation, this withanolide prevents ER stress-induced cone cell death and potentially restores partial opsin function.
Notes
IPFS: QmWzU51m3JvRX664Aw2ZbqRc4b9gdMUyHX9osZtGeneCYv. TX: 0xbd07677a4d8c0e00565d2eeaba52fa9cdbd56588eec133e39b4806a61479a1fb. CC0.
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hypothesis.json
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(367 Bytes)
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