Published April 28, 2026 | Version v1
Preprint Open

GSK-3β/HDAC6 Dual Inhibition for PSP Microtubule Stabilization

Authors/Creators

  • 1. MedicOath

Description

GSK-3β hyperphosphorylates tau promoting aggregation, while HDAC6 deacetylates α-tubulin causing microtubule destabilization in PSP neurons. Simultaneous inhibition of GSK-3β and HDAC6 would reduce pathological tau phosphorylation while promoting microtubule acetylation and stability in affected brainstem regions.

Notes

IPFS: QmYsPa6fdRvMNXX4cveuCjZNRADkTy2nSmqN4LCz11D5uQ. TX: 0xd44fc7c164bbbb6db7456f3b5d77a6477eda37d170fa47a50a905021b4772e21. CC0.

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