Published April 28, 2026 | Version v1
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Arginase-1 Inhibition to Reverse M2 Macrophage Polarization

Authors/Creators

  • 1. MedicOath

Description

CB-1158 (INCB001158) inhibits arginase-1 enzyme, preventing L-arginine depletion and restoring nitric oxide synthase (NOS2) activity in infected macrophages. This shifts macrophage polarization from permissive M2 (IL-10, TGF-β dominant) to leishmanicidal M1 phenotype (iNOS, TNF-α, IL-12 production).

Notes

IPFS: QmXSCe7Fpb12oQBV7JSiZ3pyjjnf9UjJBTbf3GNJ26cDow. TX: 0x87d118d508be9e0202ea50d7e5c33aa049a617d5a0c57ad4dcbf4635c3b31869. CC0.

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