Published April 28, 2026 | Version v1
Preprint Open

Repurposing Bromoenol Lactone for Early-Stage Alzheimer's Disease via PLA2G6 Inhibition

Authors/Creators

  • 1. MedicOath

Description

Bromoenol lactone targets PLA2G6 (pChEMBL: 6.85 from ChEMBL), which Open Targets scores at 0.88 for dementia association. PLA2G6 is involved in glycerophospholipid metabolism (KEGG: hsa00564) and arachidonic acid metabolism (hsa00590), pathways disrupted in neurodegeneration. Inhibiting PLA2G6 could reduce neuroinflammation and lipid peroxidation in early Alzheimer's.

Notes

IPFS: QmWLvR7TSCmdXsLaM9pNtTzLNp7xtR8QAv1AnQXxBqaxyn. TX: 0xd543fb5930fa3eb17d889e01afee612cf5959e526c796ff16977ac6dce802bef. CC0.

Files

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