Yokukansan Kampo Formula for Behavioral Regulation via Multi-target Neurotransmitter Modulation

This traditional Japanese seven-herb formula containing Uncaria hook, Angelica root, and Atractylodes rhizome provides multi-target effects on GABA, glutamate, and serotonin systems through compounds like geissoschizine methyl ether and atractylenolides. The formula addresses behavioral dysregulation in 47,XYY syndrome through simultaneous modulation of multiple neurotransmitter pathways involved in impulse control and emotional regulation.