Favipiravir and Ribavirin Combination for MARV RNA Polymerase Inhibition

Favipiravir (T-705) acts as a purine nucleoside analog that inhibits MARV RNA-dependent RNA polymerase (RdRp) through lethal mutagenesis and chain termination. Combination with ribavirin enhances antiviral efficacy through complementary mechanisms targeting viral RNA synthesis and potentially reducing emergence of resistant variants.