Published April 28, 2026
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Quinacrine Repurposing for PrPSc Aggregation Inhibition
Description
Quinacrine binds directly to the cellular prion protein (PrPC) and inhibits its conversion to the pathogenic scrapie form (PrPSc) by stabilizing the native α-helical structure. The drug interferes with the β-sheet formation characteristic of misfolded prions and may enhance clearance of existing aggregates through autophagy activation.
Notes
IPFS: QmbC2ypU6hBQjjQueWEyJYJDLrxE1MnYcgRYhRDHEapQAp. TX: 0x5774b4dead605eec685be171e31c52100e068d604f80fbd4b70370abdd607359. CC0.
Files
hypothesis.json
Files
(328 Bytes)
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