Rhodiola salidroside-Astragalus polysaccharide combination for mitochondrial biogenesis enhancement

Salidroside from Rhodiola rosea activates AMPK-PGC1α pathway enhancing mitochondrial biogenesis, while Astragalus polysaccharides upregulate TFAM expression and reduce oxidative stress via Nrf2 activation. This combination addresses the core mitochondrial dysfunction in methylmalonic acidemia by promoting healthy mitochondrial production and protecting existing organelles from acid-induced damage.