Published April 28, 2026
| Version v1
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Gastrodin from TCM Tianma for Pteridine Pathway Enhancement via ALDH7A1 Modulation
Description
Gastrodin, the primary bioactive compound from Gastrodia elata (Tianma), enhances aldehyde dehydrogenase ALDH7A1 activity and promotes folate-pteridine cofactor recycling. The compound upregulates sepiapterin reductase expression through CREB phosphorylation, potentially bypassing deficient 6-pyruvoyl-tetrahydropterin synthase activity by enhancing downstream BH4 synthesis pathways.
Notes
IPFS: QmenzUCA3wRjGENoFUQHVPF2pu8BpVKCtQJTu9XBCh2DRb. TX: 0xd24788f892d01c068ca0c2894275e68092e23eada0e07eb3b384fadab97d2d30. CC0.
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hypothesis.json
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