Published April 28, 2026 | Version v1
Preprint Open

Rasayana-inspired autophagy enhancement via ATG7/BECN1 modulation for AAA prevention

Authors/Creators

  • 1. MedicOath

Description

Ayurvedic Rasayana compounds (ashwagandhanolide from Withania somnifera) upregulate ATG7 and BECN1 expression, enhancing macrophage autophagy to clear oxidized LDL and reduce foam cell formation in aortic walls. Simultaneous activation of SIRT1/FOXO3 pathway promotes vascular smooth muscle cell survival.

Notes

IPFS: QmcEhurqBG45Lzu4XRB85kTkt6vNDecEsEQNyncmesNijb. TX: 0x58a776f6845dd00abdecdbb049075113f2e011f78f117ec04fbf853bccc192a2. CC0.

Files

hypothesis.json

Files (398 Bytes)

Name Size
md5:39ec0ab36d1d0c45e958f714e66e4356
398 Bytes Preview Download