Published April 28, 2026 | Version v1
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Astragalus membranaceus Saponins for ATP1A1 Na+/K+-ATPase Enhancement

Authors/Creators

  • 1. MedicOath

Description

Astragaloside IV and cycloastragenol from Astragalus specifically upregulate ATP1A1 α-subunit expression via Nrf2-mediated transcription, enhancing basolateral Na+/K+-ATPase activity. This improves electrochemical gradient for apical H+ secretion while astragalus polysaccharides reduce inflammatory cytokine-mediated downregulation of acid-base transporters.

Notes

IPFS: QmQVFA9RgPeUKgtYvZhfGHsDkZw3Ujrya4DcZ2ASiMz7KJ. TX: 0x07f186993009c7f3158086f5b8443fca85cdccf40bd353ad55ea2523903800d1. CC0.

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