Published April 28, 2026
| Version v1
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Azithromycin Combination with Rifampicin for Enhanced T. pallidum pertenue Clearance
Description
Azithromycin targets the 23S rRNA subunit of T. pallidum pertenue ribosomes, while rifampicin inhibits bacterial RNA polymerase β-subunit (rpoB). The combination provides synergistic bactericidal activity against spirochetes and reduces selection pressure for macrolide resistance mutations in the 23S rRNA gene.
Notes
IPFS: QmbZSwxVxPyvQ58Ma5J6nCA8hHzDtPXQbXZN1iCs3jKAfd. TX: 0xc9498c84cbdd9c94fa3c87d80f20a1f223628661a40f29120a9c838a8855d4f8. CC0.
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hypothesis.json
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(338 Bytes)
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