Published April 28, 2026
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Metalloproteinase Inhibition via Ursolic Acid-Gallic Acid Combination from Japanese Kampo
Description
The traditional Kampo formula Shakuyaku-kanzo-to contains ursolic acid and gallic acid that synergistically chelate zinc ions in the catalytic domain of snake venom metalloproteinases (SVMPs). This dual-targeting approach shows enhanced potency compared to single-agent EDTA, with ursolic acid providing membrane stabilization while gallic acid offers direct enzyme inhibition.
Notes
IPFS: Qmd63qAdRn4E275vdvL94cetGUJ6QR7chErfJCQEyUp8vd. TX: 0xe25f103d3a726e889e8da39b597da015a459f8559f6e590994bc96ac2b8626e1. CC0.
Files
hypothesis.json
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(375 Bytes)
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