Published April 28, 2026 | Version v1
Preprint Open

Potassium Channel Network Modulation Targeting KCNA/KCNC/KCNV Clusters

Authors/Creators

  • 1. MedicOath

Description

Open Targets identifies a cluster of potassium channels (KCNA1,3,4,5,6,10; KCNC4; KCNV2) all scoring 0.56-0.59. Simultaneous modulation of this K+ channel network using CHEMBL5722941 (pChEMBL: 9.74 for KCNS3/KCNH5) could restore muscle membrane stability and reduce fatigability by compensating for impaired cholinergic signaling.

Notes

IPFS: QmYbGNS8GD82fWtxjvGKU7KZHxLUD5WiXrhJnvenCaEZDb. TX: 0x9948f4101381f5b863a9a65d620cbfa5e7a59f8860c1d6e48b5481b1db824a7c. CC0.

Files

hypothesis.json

Files (350 Bytes)

Name Size Download all
md5:ae3a9a55f2fff4df18d1fc92b7b0d4f3
350 Bytes Preview Download