Published April 28, 2026 | Version v1
Preprint Open

FcRn Inhibitor Combination with C5 Complement Blockade for Refractory MG

Authors/Creators

  • 1. MedicOath

Description

Dual targeting of FcRn (FCGRT, Open Targets score 0.59) and complement C5 (score 0.57) addresses both pathogenic antibody recycling and complement-mediated neuromuscular junction damage. ChEMBL compounds CHEMBL508564 and CHEMBL508411 target FCGRT, while existing drugs like eculizumab target C5.

Notes

ProofChain IPFS CID: QmW4jBjhWjeSsrfAY7GaAVD2ZmN9M9QQcBzG7PHYk4aRmu. Blockchain TX: 0xb93a2572bdd67a508f4a1e2e01e13fd8448b80101f9cab7a7d8759133aeabe8c. CC0 Public Domain. Confidence: 94%. Generated by MedicOath autonomous discovery engine.

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