Formulation and Evaluation of Matrix Tablets for Sustained Drug Release

Sustained release drug delivery systems are designed to release drugs at a controlled and predetermined rate to maintain a constant therapeutic concentration in the body, thereby enhancing patient compliance and therapeutic efficacy. The present study focuses on the formulation and evaluation of matrix tablets for sustained drug release using aceclofenac as the model drug. Aceclofenac is a non-steroidal anti-inflammatory drug widely used for the management of pain and inflammation but requires frequent dosing due to its short biological half-life. The study includes the evaluation of the drug profile followed by pre-formulation studies such as solubility analysis, drug-excipient compatibility, and flow properties. Based on these parameters, matrix tablets were formulated using suitable polymers to achieve controlled drug release. The prepared formulations were evaluated for pre-compression parameters like bulk density, tapped density, and angle of repose, as well as post-compression parameters including hardness, thickness, friability, weight variation, and drug content uniformity.