Published April 30, 2026 | Version CC-BY-NC-ND 4.0

Knowledge and Attitudes Toward Topical Retinal Use in Skincare: A Survey Study

  • 1. Department of Medicinal Chemistry and Quality Control, Faculty of Pharmacy, University of Tishreen, Latakia, Syria.

Contributors

Contact person:

  • 1. Student, Faculty of Pharmacy, University of Latakia, Latakia, Syria.
  • 2. Department of Medicinal Chemistry and Quality Control, Faculty of Pharmacy, University of Tishreen, Latakia, Syria.

Description

Abstract: Retinal, a derivative of vitamin A, has a high importance in cosmetic skincare due to its ability to accelerate cell renewal and stimulate collagen production. However, there is a growing need to investigate consumers' knowledge of this active ingredient's use and side effects. This study aimed to assess knowledge and practices regarding the use of topical retinoids among Syrians. 128 Responses were collected. Two quarters of the participants were female and 18-35 years old. Most participants had a basic awareness of the benefits of retinol, especially for acne and wrinkle treatment. However, they relied on non-medical sources for information about retinal. Some participants experienced side effects such as dryness and irritation after using retinal. However, these effects did not prevent them from continuing to use it to achieve the desired results. 75% of users reported a noticeable improvement in their skin after using retinal, leading them to recommend it to others. The results of this study indicate a growing use of retinal among Syrians, highlighting the role of doctors in providing appropriate guidance on the correct method of application, including the timing and frequency of application and how to reduce its side effects.

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Identifiers

Dates

Accepted
2026-04-15
Manuscript received on 28 March 2026 | Revised Manuscript received on 04 April 2026 | Manuscript Accepted on 15 April 2026 | Manuscript published on 30 April 2026.

References

  • Mambwe, B., Mellody, K. T., Kiss, O., O'Connor, C., Bell, M., Watson, R. E. B., & Langton, A. K. (2025). Cosmetic retinoid uses in photoaged skin: A review of the compounds, their use and mechanisms of action. International journal of cosmetic science, 47(1), 45–57. DOI: https://doi.org/10.1111/ics.13013.
  • Leyden, J., Stein-Gold, L., & Weiss, J. (2017). Why Topical Retinoids Are the Mainstay of Therapy for Acne. Dermatology and therapy, 7(3), 293–304. DOI: https://doi.org/10.1007/s13555-017-0185-2.
  • Quan T. (2023). Human Skin Ageing and the Anti-Ageing Properties of Retinol. Biomolecules, 13(11), 1614. DOI: https://doi.org/10.3390/biom13111614.
  • Lin, L., Chen, X., Liu, C. et al. Comparative efficacy of topical interventions for facial photoaging: a network meta-analysis. Sci Rep 15, 26889 (2025). DOI: https://doi.org/10.1038/s41598-025-12597-0.