AEBM: System-Specific Burden Matrix of Anabolic-Androgenic Steroids - a FOA Extension, v1.0

The use of anabolic-androgenic steroids (AAS) in performance and optimisation contexts is commonly interpreted through simplified dose-response paradigms that fail to account for system-level biological complexity. While supraphysiological androgen exposure reliably increases signal intensity within the Functional Androgen Axis (FOA), functional outcomes are constrained by system capacity and nonlinear burden accumulation across multiple physiological domains.

This paper introduces the System-Specific Burden Matrix (AEBM) as a formal extension of the FOA framework. The AEBM integrates androgenic functional yield with domain-specific biological burden across five physiological systems: hepatic, cardiovascular, endocrine-reproductive, renal, and neuropsychiatric.

For each of 10 AAS compounds (testosterone, nandrolone, boldenone, trenbolone, oxandrolone, stanozolol, oxymetholone, methandienone, drostanolone, metenolone), the AEBM quantifies:
- Functional Yield (FY): expected androgenic signal contribution
- Burden-to-Yield Ratio (BYR): ratio of total systemic burden to functional output
- Domain-specific burden profiles across all five systems

The framework provides a methodological basis for evidence-informed compound selection and harm reduction in clinical and advisory contexts.

Author: Jakub Czernikiewicz, CZERNIHealth (czernihealth.pl)