Pharmacological Evaluation of Anti-Parkinson Activity of 'Ananas comosus' Fruits Ethanolic Extract in Mice

Objective: The purpose of the study was to assess the neuroprotective potential of ethanolic extract from the pineapple fruit (Ananas comosus) against MPTP-induced Parkinsonism in mice.
Method: Five groups of male Swiss mice weighing between 30 and 35 grammes were randomly assigned: control, disease (MPTP 20 mg/kg), standard (Syndopa 10 mg/kg + MPTP), low dose extract (200 mg/kg + MPTP), and high dose extract (400 mg/kg + MPTP). For seven days, MPTP was injected intraperitoneally to produce symptoms similar to Parkinson's disease. On day seven, behavioural tests were performed, such as the Rota rod, Hanging/Grip, Forced Swim, Elevated Plus Maze, Catalepsy, Open Field, and Actophotometer tests. Water intake, feed, and body weight were also noted.

Results:MPTP caused anxiety-like behaviour and markedly hampered motor coordination and movement. Performance in every behavioural test was significantly enhanced by treatment with Ananas comosus extract. Superior outcomes were demonstrated by the high-dose extract, which was on par with the standard Syndopa group. Better feed and water intake, decreased anxiety and catalepsy, and improved motor coordination were among the improvements.
Conclusion:Ethanolic extract from Ananas comosus significantly protects mice from MPTP-induced Parkinsonism. Its potential as a supplemental treatment for neurodegenerative diseases like Parkinson's disease.