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Published April 15, 2026 | Version 0.1
Dataset Open

iSCORE-PD: scRNA-seq of irradiated WIBR3 hESCs

Authors/Creators

  • 1. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA,& Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, 1301 Morris Park Ave., Bronx, NY 10461, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
  • 2. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA,& Innovative Genomics Institute, University of California, Berkeley, CA, 94720, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
  • 3. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
  • 4. Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA,& Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK
  • 5. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
  • 6. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
  • 7. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
  • 8. Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Ave., Bronx, NY 10461,USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
  • 9. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA,& Department of Neuroscience, University of California, Berkeley, Berkeley, CA 94720, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
  • 10. Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA
  • 11. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD,20892, US.
  • 12. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.
  • 13. LiftOff Biosolution. 813 Isbel Ct, Santa Cruz 95060, USA.
  • 14. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA,& Department of Neuroscience, University of California, Berkeley, Berkeley, CA 94720, USA,& Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
  • 15. Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA,& Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD,20892, US
  • 16. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA,& Innovative Genomics Institute, University of California, Berkeley, CA, 94720, USA,& Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
  • 17. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA,& Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, 1301 Morris Park Ave., Bronx, NY 10461, USA,& Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Ave., Bronx, NY 10461,USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA

Description

This Zenodo deposit contains a publicly available description of the Dataset:

Title: "iSCORE-PD: scRNA-seq of irradiated WIBR3 hESCs".

Description: Single-cell RNA sequencing of WIBR3 human embryonic stem cells (hESCs) exposed to ionizing radiation at doses of 0, 0.5, 2, 5, and 10 Gy. Cells were assayed 24h post-irradiation via multiplexed scRNASeq using MULTI-seq reagents.

This dataset is made available to researchers via the ASAP CRN Cloud: cloud.parkinsonsroadmap.org. Instructions for how to request access can be found in the User Manual.

This research was funded by the Aligning Science Across Parkinson's Collaborative Research Network (ASAP CRN), through the Michael J. Fox Foundation for Parkinson's Research (MJFF).

This Zenodo deposit was created by the ASAP CRN Cloud staff on behalf of the dataset authors. It provides a citable reference for a CRN Cloud Dataset

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References