AI-assisted computational exploration of estradiol-serotonin pathway gene regulation in the human brain: preliminary findings requiring independent validation

This preprint reports AI-generated computational findings from six publicly available transcriptomic and epigenomic datasets (GTEx v8, GEO GSE168292, GEO GSE126870, HYPOMAP, CELLxGENE Census, ReMap 2022), exploring the hypothesis that estradiol receptor signaling regulates serotonin pathway gene expression in the human brain. All analyses were performed by Edison Scientific Kosmos, a commercial AI-assisted platform. No human bioinformatician independently verified the pipelines. The findings are reported transparently as testable predictions requiring independent validation. A companion clinical hypothesis paper is under review at a peer-reviewed journal.