Cardioprotective Potential of Polyherbal Formulations: A Critical Review

Cardiovascular disease are the most common cause of death worldwide, , especially in developed and developing countries, it plays a major role in increasing mortality rates [1]. Hypertension, myocardial infarction, cardiomyopathy and heart failure continue to emerge as major public health problems that warrant the development of safer and more effective therapeutic strategies. While synthetic cardioprotective medicines including beta-blockers, calcium channel blockers, ACE inhibitors, and statins are commonly employed, the nonlinear administration of these medications is frequently accompanied by defects and toxicity. [1,2] Traditional medicinal systems rely on herbal drugs, especially polyherbal formulations for the management of cardiac disorders. Polyherbal therapy is based on the idea of synergism, where different herbs work together to improve effectiveness and reduce toxicity.The present systematically reviews commonly used medicinal plants in cardiac polyherbal formulations, their phytoconstituents, mechanisms of action, and experimental evaluation methods. Furthermore, issues related to standardization, quality control, and marketed formulations are discussed.Evidence suggests that polyherbal formulations exert cardioprotective effects through antioxidant, anti-inflammatory, antihyperlipidemic, and membrane-stabilizing mechanisms. However, the lack of large-scale clinical validation remains a major limitation. Future research should focus on molecular mechanism studies, clinical trials, and advanced drug delivery systems for improved therapeutic outcomes.