"Revolutionizing Cancer Care: CAR T-Cell Therapy and the Expanding Role of Nurses in Advanced Immunotherapy"

Abstract: Chimeric Antigen Receptor (CAR) T-cell therapy represents a groundbreaking advancement in cancer treatment, particularly for hematological malignancies. By genetically modifying a patient’s own T lymphocytes to recognize and destroy cancer cells, CAR T-cell therapy has demonstrated remarkable success in cases resistant to conventional treatments. However, this innovative therapy is associated with complex procedures and potentially life-threatening toxicities, necessitating specialized and vigilant nursing care. Nurses play a pivotal role across the continuum of CAR T-cell therapy—from patient selection and education to post-infusion monitoring and long-term follow-up. This review article explores the principles, process, clinical applications, complications, and future prospects of CAR T-cell therapy, while emphasizing the critical contributions of nurses in ensuring patient safety, therapeutic effectiveness, and holistic care. The integration of advanced clinical knowledge, patient-centered communication, and interdisciplinary collaboration is essential for optimizing outcomes in patients undergoing CAR T-cell therapy.