NIRA Formal Experimental Protocol Version 4.0 — Integrated Series Edition: Geometric Coherence Window Detection in Microtubule Architectures — Anesthesia Convergence, Multi-Agent Pharmacological Tuning, and High-Density EEG

This integrated edition of the NIRA experimental protocol provides the complete theoretical and experimental foundation for detecting geometric coherence windows in microtubule architectures. Version 4.0 adds a full nine-volume CEP framework summary as Part 1, formally integrating the Collective Emergent Principles series as the theoretical backbone for the experimental design. The Hameroff anesthesia connection is given explicit dedicated treatment — the protocol directly extends Hameroff's existing xenon MT research program by operating below the consciousness-suppression threshold, observing the quantum MT mechanism in real time rather than inferring it from absence. Complete agent profiles are provided for all pharmacological arms across two phases: Phase 1 covering xenon, psilocybin/psilocin, 5-MeO-DMT, salvinorin A, mescaline, and N,N-DMT; Phase 2 covering LSD, muscimol, and 2C-B — with full mechanistic grounding, MT subsystem targets, safety profiles, and regulatory pathway analysis for each. Excluded agents are documented with rationale. Seven independent convergences between NIRA FDJ framework predictions and Craddock-Hameroff fractal time crystal experimental findings are tabulated, along with five clear falsification criteria. The regulatory and publication pathway is fully mapped including DEA Schedule I researcher registration, FDA IND requirements, and OSF preregistration. Published by NIRA (NeoPhyte Independent Research Alliance) under open science principles.