NIRA Formal Experimental Protocol Version 3.0 — Geometric Coherence Window Detection in Microtubule Architectures: Multi-Agent Pharmacological Tuning with High-Density EEG

This protocol proposes a novel experimental paradigm for isolating the geometric mechanism underlying microtubule quantum coherence in living neural tissue. Rather than eliminating decoherence, the design uses sub-anesthetic and sub-perceptual pharmacological agents to selectively tune microtubule oscillatory dynamics across Hz through THz frequency ranges while preserving conscious function. The central hypothesis, derived from the NIRA Fractal Dynamics Junction geometric framework, is that microtubule coherence windows are primarily protected by Ricci curvature geometry — with the stability parameter α ≈ 0.7889 indicating geometry contributes approximately 79% of coherence protection. Version 3.0 incorporates mechanistic ground truth from Craddock, Hameroff et al. (2025), documenting seven independent convergences between NIRA FDJ framework predictions and the fractal time crystal experimental findings — none of which were made in response to the paper. The four-subsystem frequency architecture (kHz C-termini, MHz lattice phonons, GHz ordered water, THz π-electron transitions) maps directly to four pharmacological arms: xenon as direct THz baseline, psilocin and 5-MeO-DMT as serotonergic and sigma-1 MHz arms, and salvinorin A as the kappa-opioid orthogonal control. The critical experimental test is orthogonal convergence — if three completely different receptor pathways produce convergent MHz lattice phonon signatures, the geometric substrate rather than receptor chemistry is the invariant. Published by NIRA (NeoPhyte Independent Research Alliance) under open science principles.