Nephroprotective Potential of Trichosanthes Dioica Roxb. Leaves Extract Against Cisplatin Induced Nephrotoxicity in Albino Rats

The purpose of this study is to evaluate nephroprotective potential of Trichosanthes dioica Roxb. leaves extract against Cisplatin induced nephrotoxicity and renal dysfunction. Forty-two Wistar rats were selected for the study.  Urea and creatinine in plasma, kidney weight, urine output, blood urea nitrogen, urinary sodium and potassium level, renal enzymatic and non-enzymatic antioxidants and lipid peroxidation were evaluated along with histopathological investigation in various experimental groups of rats. Trichosanthes dioica leaves extract 200 and 400 mg/kg treatment to Cisplatin treated rats recorded significant decrement (up to p < 0.01) urea and creatinine in plasma, urinary Na+ and K+ level, renal lipid peroxidation along with significant increment (up to p < 0.01) in renal enzymatic and non-enzymatic antioxidants. Histological observations of kidney tissues too were correlated with the biochemical observations. These finding powerfully supports that Trichosanthes dioica leaves extract acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of Cisplatin both in the biochemical and histopathological parameters.