Fixed Drug Eruption Secondary to Doxycycline: A Case Report

Introduction: A fixed drug eruption (FDE) is a unique skin allergic reaction that is characterised by recurrence of lesions at the same spot every time a specific drug is ingested. Generally, presents as well- defined red, violet, or dark brown patches or plaques. Frequently seen with some antimicrobial agents like tetracyclines, Sulfamethoxazole and others like NSAIDs. The lesions regress after cessation of the drug, but leave a lingering, permanent, dark brown hyperpigmentation.

Patient concerns: A 58-year-old male with the complaint of ulceration of mouth, dusky red annular patches over forearms, hand, palms and soles, along with redness of the scrotal region was admitted to the Dermatology ward of Silchar Medical College and Hospital. The lesions started 2 days after the intake of Tab. Doxycycline and gradually progressed in size and shape.

Diagnosis: The patient was diagnosed with Fixed drug eruption secondary to doxycycline based on his drug history, clinical manifestations, and laboratory test results.

Interventions: The patient was administered intravenous glucocorticoids along with Inj. Ceftriaxone and the patient’s condition improved after treatment.

Outcomes: After receiving therapy, the patient's condition slowly improved, the lesions faded, and the burning sensation subsided.

Conclusion: Case reports are crucial as they highlight the regional prescribing patterns and the ADRs that can follow. Established protocols for diagnosing and managing Fixed Drug Eruption (FDE) in India are largely derived from dermatological clinical studies and case reports. Also, case reports can help in an in-depth understanding of the reaction, along with the variety of its clinical manifestations. Hence, a case report on fixed drug eruption secondary to doxycycline has been presented.