Nanotechnology-Based Drug Delivery Systems for Combating Antimicrobial Resistance: A Systematic Review and Meta-Analysis

Background: Antimicrobial resistance (AMR) is a growing global health concern that limits the effectiveness of conventional therapies. Nanotechnology-based drug delivery systems have emerged as a promising strategy to enhance antimicrobial efficacy.

Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA 2020 guidelines. Relevant studies were identified through database searches using predefined inclusion criteria. A random-effects model was applied to estimate pooled effect sizes.

Results: A total of 18 studies were included. The pooled odds ratio was 2.85 (95% CI: 2.10–3.60; I² = 58%), indicating a statistically significant improvement in antimicrobial efficacy with nanotechnology-based delivery systems compared to conventional treatments.

Conclusion: Nanotechnology-based drug delivery systems significantly enhance antimicrobial outcomes and represent a promising approach to combat AMR. However, further large-scale clinical studies are required to confirm their clinical applicability.