Single-Cell Transcriptomic Identification of Novel Drug Repurposing Candidates for Heart Failure and Dilated Cardiomyopathy via Human Left Ventricular scRNA-seq (GSE161470)

Companion preprint to USPTO provisional patent application. Applies a 12-step computational pipeline to GSE161470 (Hu et al., human left ventricular scRNA-seq, 9,803 cells, DCM vs. normal). Reports cell-type-resolved differential expression, ChEMBL bioactivity screening (17,793 candidates), and PubChem novelty filtering identifying LESTAURTINIB, R-406, FORETINIB, CERDULATINIB, DASATINIB, and CHEMBL5653589 as novel repurposing candidates targeting the CSF1R/SYK macrophage inflammatory axis and cytoskeletal remodeling pathways. Authors: Glen Charles Ritschel (Ritschel Research, Tega Cay SC) and Claude (Anthropic, San Francisco CA). CC BY 4.0.