Design, Development And In Vitro Characterization of A Sensitive Nanoparticles Drug Delivery System for Targeted Delivery of An Anticancer Drug

Cancer chemotherapy has limitations to its therapeutic effectiveness including lack of specificity of drug distribution, systemic toxicity, low bioavailability and multidrug resistance. Stimuli-sensitive nanoparticle drug delivery systems have emerged as a promising solution to these issues, allowing for the targeted and controlled delivery of anticancer drugs. These intelligent nanoparticles are crafted to react to various internal stimuli like pH levels, redox conditions, and enzymatic activity, as well as external factors such as temperature, light, and magnetic fields. This is due to the fact that this capability enables the precise release of drugs within the tumor microenvironment. The review offers a thorough account of how stimuli-sensitive nanoparticle drug delivery systems have been designed, developed, and characterized in vitro, all with the goal of delivering drugs to targeted animals for cancer treatment. Types of nanoparticles, fabrication, design considerations, in vitro assessment of their physicochemical and biological characteristics are reviewed and recent advances in the area discussed as well. The review highlights the current issues and future perspectives concerning the clinical transfer of smart nanoparticle systems emphasizing on their potential to positively influence therapeutic effects and to decrease the adverse effects.