Controlled Release Polymeric Materials for Multifunctional Applications

Delivery of drugs by new technologies is a highly topical challenge of polymer chemistry. This report describes the preparation of antibacterial activated poly(styrene–alt–maleic anhydride) (PSMA) in which aminophenyl antibiotic is covalently bonded onto the polymeric framework. The prepared copolymers were purified and their structures characterized by FT-IR spectroscopy. In vitro drug releasing was performed under specific conditions to investigate the influence of pH on the releasing rate. Poly(Styrene co-maleic anhydride) (SMA) is a synthetic copolymer with interesting chemical and biological properties. The anhydride group can also easily react with hydroxyl and amine containing compounds viz aminobenzoic acid at 90 0C to obtained modified SMA polymer with high yield. The Tg of the polymer were higher than that of SMA due to H-bonding interaction between the polymer chains. The detailed structural study of polymer complexes was done using method of molecular spectroscopy.The antiproliferative activity of poly(styrene–alt–maleic anhydride) released from polymer towards MCF-7 (human breast cancer) and BALB/3T3 (murine fibroblast) cell lines was evaluated. Moreover, antimicrobial potency of the released drug was tested against (Bacillus subtilis and Escherichia coli as a Gram positive and Gram negative bacterial pathogen, while Candida albicans was used as a pathogenic yeast