Advances in Herbal Anti-Acne Delivery Systems: Role of Marigold and Neem in Polyherbal Patch Technology

Acne vulgaris is a prevalent dermatological disorder characterized by excessive sebum production, follicular hyperkeratinization, bacterial colonization, and inflammation. While conventional therapies such as antibiotics, retinoids, and chemical peels offer clinical benefits, they are often associated with side effects, irritation, microbial resistance, and reduced patient compliance. This has led to growing interest in herbal remedies, which provide a gentler and holistic approach to skin health. Among these, neem (Azadirachta indica) and marigold (Calendula officinalis) have shown significant potential due to their complementary pharmacological activities. Neem exhibits antimicrobial and sebum-regulating properties, reducing bacterial load and controlling oiliness, whereas marigold offers anti-inflammatory, antioxidant, and regenerative benefits, promoting healing of damaged skin. Polyherbal patch technology emerges as an innovative strategy to deliver these botanicals directly to affected areas in a controlled and sustained manner, enhancing therapeutic efficacy while minimizing systemic exposure and improving patient compliance. Modern formulation approaches, including solvent casting, biocompatible polymers, and nanocarrier integration, have enabled the development of stable, effective, and safe herbal patches. Preclinical and limited clinical studies support their anti-acne potential and skin tolerability. Despite these promising outcomes, challenges such as batch-to-batch variability, skin permeability barriers, stability concerns, and regulatory considerations must be addressed. Future research focusing on smart patches, nanotechnology, eco-friendly polymers, and rigorous clinical evaluation could pave the way for translating these polyherbal systems into practical, patient-friendly therapies. In conclusion, neem–marigold polyherbal patches represent a convergence of traditional herbal wisdom and modern drug delivery science, offering a safe, multi-targeted, and sustainable approach to acne management