CHANGES IN INSULIN LIKE GROWTH FACTOR 1, BONE MINERAL DENSITY AND MUSCLE MASS IN ELDERLY PATIENTS WITH COPD

Backgroud: COPD is a highly prevalent systemic disease in the elderly population and it is considered as a major health problem in Egypt, However information on its prevalence, morbidity, and mortality is still lacking.COPD has a variety of extra-pulmonary manifestations and our study was conducted to determine the changes in insulin like growth factor-1, Bone mineral density and muscle mass in elderly people with COPD.

Material and Methods: case control study conducted on 90 elderly participants and they were classified into two groups:

Cases Group:

Forty five patients diagnosed to have COPD either mild or moderate.

Control Group:

Forty five healthy subjects, age and gender matched to cases recruited from the community

Both groups were subjected to detailed history taking and clinical examination, comprehensive geriatric assessment, spirometry , measurement of serum IGF-1, DXA scan to determine BMD and muscle mass.

Results: The study showed that elderly COPD patients had a lower level of IGF-1 (106.1) compared with control group (184.6) which is lower by 42%and a lower BMD in the cases group (1.15) compared to the control group (1.52) and also a lower muscle mass (47465)  when compared to normal elderly(49400).

Conclusion: the study concluded that COPD patients had a lower mean level of IGF-1,BMD and Muscle mass than normal elderly