FORMULATION AND EVALUATION ANTISEPTIC ACTIVITY OF POLYHERBAL CREAM
Authors/Creators
- 1. Associate Professor, Department of Pharmaceutics, Karuna College of PHARMACY, Thirumittacode, Kerala, India.
- 2. Professor & Principal, Department of Pharmaceutical Analysis, Karuna College of Pharmacy, Thirumittacode, Kerala, India.
- 3. Professor and Vice Principal, Department of Pharmaceutical Analysis, Karuna College of Pharmacy, Thirumittacode, Kerala, India.
- 4. M.Pharm, Assistant Professor, Karuna College of Pharmacy, Thirumittacode, Kerala, India.
- 5. Research Scholar, Department of Pharmaceutics, Karuna College of PHARMACY, Thirumittacode, Kerala, India.
Description
Herbal formulations have gained significant importance due to their safety, cost-effectiveness, and minimal side effects when compared to synthetic products. The present study was aimed at the formulation and evaluation of a polyherbal cream with antiseptic activity using natural plant extracts of Azadirachta indica (Neem), Plectranthus amboinicus (Mexican mint), and Aloe barbadensis (Aloe vera). These plants are well known for their antimicrobial, anti-inflammatory, and wound-healing properties. The polyherbal cream was prepared using suitable excipients by incorporating hydroalcoholic extracts of the selected plants. The formulated cream was evaluated for physicochemical parameters such as appearance, pH, viscosity, spread-ability, homogeneity, wash-ability, and stability. The antiseptic activity of the formulation was assessed using the agar well diffusion method against selected pathogenic microorganisms, including Escherichia coli and Staphylococcus aureus, by measuring the zone of inhibition. The results demonstrated that the polyherbal cream showed satisfactory physicochemical properties and good stability. The formulation exhibited significant antimicrobial activity, indicating a synergistic effect of the combined herbal extracts. The study concludes that the developed polyherbal cream possesses effective antiseptic activity and can serve as a safe and natural alternative to conventional antiseptic creams.
Files
54 WJPSR 2214.pdf
Files
(767.2 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:ee74278e7e6234816889376eb24e90cf
|
767.2 kB | Preview Download |
Additional details
References
- 1. Priyanka Sharma, Amit C Kharkwal, Harsha Kharkwal, MZ Abdin, Ajit Varma, A review on the pharmacological properties of Aloe vera, International Journal of Pharmaceutical Sciences Review and Research, 2014; 29: 31–37.
- 2. Sharma Pankaj, Tomar Lokeshwar, Bachwani Mukesh, Bansal Vishnu, Review on neem (Azadirachta indica): thousand problems one solution, International Research Journal of Pharmacy, 2011; 2: 97–102.
- 3. KP Sampath Kumar, Debjit Bhowmik, Biswajit, Chiranjib, Pankaj, KK Tripathi, Margret Chandira, Traditional Indian herbal plants Tulsi and its medical importance: a review, Research and Reviews: Journal of Pharmacognosy and Phytochemistry, 2010; 2: 103–108.
- 4. Renisheya Joy Jeba Malar T, Johnson M, Nancy Beaulah S, Laju RS, Anupriya G, Renola Joy Jeba Ethal T, Anti-bacterial and anti-fungal activity of aloe vera gel extract, International Journal of Biomedical and Advance Research, 2012; 3: 184–187.
- 5. Zingue S, Kaga Silihe K, Fouba Bourfane I, et al, Potential of regular consumption of Cameroonian neem (Azadirachta indica L.) oil for prevention of the 7,12-dimethylbenz(a)anthracene-induced breast cancer in high-fat/sucrose-fed Wistar rats, Evidence-Based Complementary and Alternative Medicine, 2019; 2019: 2031460.
- 6. Márcia Santos Filipe, Gabrielle Bangay, Florencia Z Brauning, Festus Oladayo Ogungbemi, Bernardo Brito Palma, Ana María Díaz-Lanza, Amr Hassa, Rebeca André, Patricia Rijo, Plectranthus amboinicus: a systematic review of traditional uses, phytochemical properties, and therapeutic applications, 2025; : 1–5.
- 7. Siddhant Hagavane, Sneha Sonawane, Akshay Katkale, Vishvam Kunde, Review on cream as topical drug delivery system, 2022; 7(1): 21–30.
- 8. Aslam F, Rehman KU, Asghar M, Sarwar M, Antibacterial activity of various phytoconstituents of neem, Pakistan Journal of Agricultural Sciences, 2009; 46(3): 209–213.
- 9. Banerjee S, Kim LM, Shariff M, Khatoon H, Yusoff SM, Antibacterial activity of neem (Azadirachta indica) leaves on Vibrio spp. isolated from cultured shrimp, Asian Journal of Animal and Veterinary Advances, 2012; : 1–7.
- 10. Divya Kumari P, Shenoy SM, Khijmatgar S, Chowdhury A, Chowdhury CR, Antibacterial activity of new atraumatic restorative treatment materials incorporated with Azadirachta indica (neem) against Streptococcus mutans, Journal of Oral Biology and Craniofacial Research, 2019; 9(4): 321–325.
- 11. Nikhil Nitin Navindgikar, KA Kamalapurakar, Prashand S Chavar, Formulation and evaluation of multipurpose herbal cream, Research, 2020; 12(3): 25–30.
- 12. Mafou-Sonhafouo V, Kana JR, Nguepi-Dongmo K, Effects of graded levels of Azadirachta indica seed oil on growth performance and biochemical profiles of broiler chickens, Veterinary Medicine and Science, 2019; 5(3): 442–450.
- 13. Jayshree Modi, Sunayaya Rathore, Sunil Dwivedi, Gauravkant Saraogi, Formulation and evaluation of multipurpose herbal cream, International Journal of Newgen Research in Pharmacy and Healthcare, 2024.
- 14. A Tripathy, Ashok Raichur, Natarajan Chandrasekaran, Amitava Mukherjee, FTIR spectra recorded by making KBr disc with fresh neem leaves extract of Azadirachta indica, 2025.
- 15. Amandha Vollmer, Healing with DMSO: the complete guide to safe and natural treatments for managing pain, inflammation, and other chronic ailments with dimethyl sulfoxide, 2025; : 1–2.
- 16. Manikandan Selvarasasuvaski, Ganapathy Murugan, Alagu Lakshmanan, Ansar Ali, Identification of bioactive compounds from selected Plectranthus species by infrared spectroscopy, 2017.
- 17. Abhijit Sadashiv Patil, Gargi Sharad Barge, Meera Deokar, Research paper on formulation and evaluation of herbal antiseptic cream, 2025; 10(2): 2237–2252.
- 18. Barua DR, Basavanna JM, Varghese RK, Efficacy of neem extract and three antimicrobial agents incorporated into tissue conditioner in inhibiting the growth of C. albicans and S. mutans, Journal of Clinical and Diagnostic Research, 2017; 11(5): ZC97–101.
- 19. Rajasree P, Jessen George, Gritta Sebastain, Gowda DV, Formulation, phytochemical screening and physico-chemical evaluation of an antiseptic ointment containing Azadirachta indica and Chromolaena odorata, International Journal of Pharmacy and Biological Sciences, 2015; 5: 114–118.
- 20. R Chandrasekar, B Sivagami, Formulation and evaluation of a poly herbal skin care cream containing neem and tulsi, 2018; 9.