Standardized Processing and Visualization of PK-Sim PBPK Outputs in R

This R script provides a standardized workflow for processing and visualizing physiologically-based pharmacokinetic (PBPK) simulation outputs generated from PK-Sim.

The script reads CSV exports from PK-Sim, harmonizes tissue naming, resolves inconsistencies in plasma representation, and generates consistent concentration–time plots across tissues.

Key features include:

• Automatic detection and conversion of time units

• Standardized mapping of tissue compartments

• Deduplication of plasma outputs

• Log-scale visualization of concentration profiles

• Consistent formatting across multiple simulations

The script was developed as part of a PBPK modelling validation workflow to ensure reproducibility and comparability of simulation outputs.