DESIGN AND DEVELOPMENT OF BUDESONIDE COLON SPECIFIC DRUG DELIVERY SYSTEM FOR INFLAMMATORY BOWEL DISEASE

In present work Colon targeting drug delivery system was developed for Budesonide drug by using combination of delayed systems one is pH dependent and other is time dependent delayed system. Rapid release core tablet (RRCT) formulations were prepared using Budesonide drug with different disintegrating agents in different concentrations. The pre-compression and post-compression parameters of all formulations were determined and the values were found to be satisfactory. From the In-vitro dissolution studies, F4 formulation with crospovidone was the best formulation. For optimized formulation press coat was done by using Guar gum and Eudragit in different ratios. Press coated tablet delays the drug release up to 8 hours based on the nature and concentrations of the polymer. As a result of this study it may be concluded that the colon targeted drug delivery tablets using a combination of two polymers in optimized concentrations can be used to increase the delayed action of drug release to deliver the drug in a delayed manner.

Keywords: Colon specific, Budesonide, FTIR studies, Natural polymers, Coating tablets, In vitro drug release studies