Glucagon-Like Peptide-1 Receptor Agonists Across the Heart Failure Spectrum: A Systematic Review and Meta-Analysis

Complete reproducible archive for a systematic review and meta-analysis evaluating GLP-1 receptor agonists across the heart failure spectrum (PROSPERO CRD420261299844). Includes raw search exports, screening data, extracted outcomes, R analysis scripts (meta-analysis, forest plots, sensitivity, subgroups, GRADE), rendered manuscript, and supplementary materials.

14 studies (6 dedicated HF trials + 8 CVOT HF subgroup analyses) encompassing 18,558 patients. Primary composite of cardiovascular death and heart failure hospitalization: HR 0.86 (95% CI 0.73–1.01, P=0.067). All-cause mortality significantly reduced: HR 0.87 (95% CI 0.81–0.93, P<0.001, I²=0%).

Searches: PubMed, Cochrane CENTRAL, ClinicalTrials.gov through February 2026.

Analysis: R (meta, metafor, dmetar) with REML + Hartung-Knapp-Sidik-Jonkman adjustment.