Vitamin B12 and Cancer: A Systematic Review of the Evidence for both Protective and Promotional Effects
- 1. International Journal of Dental Science and Innovative Research (IJDSIR)
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Abstract
Background and Aim: DNA synthesis and cellular metabolism depend on vitamin B12. Emerging research indicates that excessive supplementing may raise the risk of cancer, even as moderate doses may offer protection against some malignancies. The preventive and promoting effects of vitamin B12 on cancer are assessed in this systematic study. The aim of the study is to synthesise existing evidence to clarify the complex association between Vitamin B12 intake, serum levels, and cancer risk.
Methods: Clinical trials and observational studies published in English were found by a thorough search of major scientific databases. Only abstracts, in vitro experiments, and animal studies were not included. Four of the 300 articles that were screened satisfied the requirements for eligibility. Serum B12 levels, dietary intake, supplementation, and cancer-related outcomes were also examined. The OHAT technique was used to evaluate the risk of bias.
Results: A higher incidence of colorectal and total cancer was linked to high-dose supplementation (≥500 μg/day). Serum B12 levels in cancer patients were significantly higher (>800 pg/mL) and were correlated with tumor stage. On the other hand, a decreased risk of colorectal cancer was associated with a sufficient dietary B12 consumption from natural food sources. A lower risk of oesophageal precancerous lesions was likewise linked to higher levels of transcobalamin II and serum B12.
Conclusion: There are two connections between vitamin B12 and cancer. While avoidable long-term high-dose supplementation may raise the risk of cancer, maintaining appropriate physiological levels is advantageous. Until a clinical deficiency is established, dietary sources should be given priority.
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- 1. Office of Dietary Supplements (6 April 2021). "Vitamin B12: Fact Sheet for Health Professionals". Bethesda, Maryland: US National Institutes of Health. Archived from the original on 2021-10-08. Retrieved 24 December 2021. 2. institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B(6), Folate, Vitamin B(12), Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academies Press; 1998. 3. Allen LH. Vitamin B12. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:812-20. 4. Yamada K (2013). "Cobalt: Its Role in Health and Disease". In Sigel A, Sigel H, Sigel RK (eds.). Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. Vol. 13. Springer. pp. 295–320. doi:10.1007/978-94-007-7500-8_9. ISBN 978-94-007-7499-5. PMID 24470095 5. Calderón-Ospina CA, Nava-Mesa MO (January 2020). "B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin". CNS Neurosci Ther. 26 (1): 5–13. doi: 10.1111/cns.13207. PMC 6930825. PMID 31490017 6. "Vitamin B12". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. 4 June 2015. Archived from the original on 29 October 2019. Retrieved 5 April 2019. 7. Vincenti A, Bertuzzo L, Limitone A, D'Antona G, Cena H (June 2021). "Perspective: Practical Approach to Preventing Subclinical B12 Deficiency in Elderly Population". Nutrients. 13 (6): 1913. doi: 10.3390/nu13061913. PMC 8226782. PMID 34199569 8. Watanabe F, Bito T (January 2018). "Vitamin B12 sources and microbial interaction". Exp Biol Med (Maywood). 243 (2): 148–158. doi:10.1177/ 1535370 217746612. PMC 5788147. PMID 29216732 9. Finkelstein JL, Fothergill A, Venkatramanan S, Layden AJ, Williams JL, Crider KS, et al. (Cochrane Pregnancy and Childbirth Group) (January 2024). "Vitamin B12 supplementation during pregnancy for maternal and child health outcomes". The Cochrane Database of Systematic Reviews. 1 (1): CD 013823. doi:10.1002/14651858.CD013823.pub2. PMC 10772977. PMID 38189492 10. Stabler SP (2020). "Vitamin B12". In Marriott BP, Birt DF, Stallings VA, Yates AA (eds.). Present Knowledge in Nutrition, Eleventh Edition. London: Academic Press (Elsevier). pp. 257–272. ISBN 978-0-323-66162-1. US survey data from the NHANES What We Eat in America 2013e16 cohort reported the median vitamin B12 consumption for all adult men of 5.1 mcg and women of 3.5 mcg.95b Using the Estimated Average Requirement (EAR) for adults for Vitamin B12 of 2 mcg,93 less than 3% of men and 8% of women in the United States had inadequate diets using this comparator. However, 11% of girls 14e18 years had intakes less than their EAR of 2.0 mcg 11. Choudhury A, Jena A, Jearth V, Dutta AK, Makharia G, Dutta U, et al. (May 2023). "Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis". Expert Rev Gastroenterol Hepatol. 17 (5): 479–487. doi:10. 1080/17474124.2023.2204229. PMID 37060552. 12. "Antacid Drug Use and Risk of Esophageal and Gastric Adenocarcinomas in Los Angeles County" Authors: Lei Duan, Anna H. Wu, Jane Sullivan-Halley, Leslie Bernstein Published in: Cancer Epidemiology, Biomarkers & Prevention, February 10, 2009 13. High Plasma Vitamin B12 and Cancer in Human Studies: A Scoping Review to Judge Causality and Alternative Explanations" Authors: Rima Obeid and colleagues Published in: Nutrients, 2022 14. Article: "High Vitamin B12 Levels and Cancer: What's the Connection?" Authors: Morgan Spicer, Medical Communications Manager Published in: Everlywell Blog, November 30, 2023 15. "Elevated Vitamin B12, Risk of Cancer, and Mortality: A Systematic Review" Authors: Sandra B Amado-Garzona, Luisana Molina-Pimientaa, Andrea Vejarano-Pomboa, Mariana Vélez-Bonillaa, Jaime Moreno-Chaparrob, and Adriana Buitrago-Lopezb Published in: Cancer Investigation, 2024 16. Kim Y-I. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev. 2004;13(4):511–9. doi: 10.1158/1055-9965. 511.13.4 17. Sanjoaquin MA, Allen N, Couto E, Roddam AW, KeyTJ. Folate intake and colorectal cancer risk: a meta analytical approach. Int J Cancer. 2005;113(5): 825-828. 18. Ames BN. DNA damage from micronutrient defi ciencies is likely to be a major cause of cancer. Mutat Res. 2001;475(1-2):7-20. 19. Larsson SC, Giovannucci E, Wolk A. Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst. 2007;99(1):64-76. 20. Butterworth, C. E. Effect of folate on cervical cancer. Ann. N. Y. Acad. Sci., 669: 293±299, 1992. 21. Ebbing M, Bonaa KH, Nygard O, Arnesen E, Ueland PM, Nordrehaug JE, et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 2009;302:2119–26. 22. Xiao Q, Freedman ND, Ren J, Hollenbeck AR, Abnet CC, Park Y (2014) Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study. Br J Cancer 110(5):1328–1333 23. Hultdin J, Van Guelpen B, Bergh A, Hallmans G, Stattin P (2005) Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. Int J Cancer 113(5):819–824. https ://doi. org/10.1002/ijc.20646 24. He J, Fu H, Li C, Deng Z, Chang H. Association be tween Vitamin B12 and risk of gastric cancer: a sys tematic review and meta-analysis of epidemiological studies. Nutr Cancer. 2022;74(9):3263–73. doi: 10.1080/01635581.2022.2074062 25. Luu HN, Wang R, Jin A, Koh W-P, Yuan J-M. The association between dietary vitamin B12 and lung cancer risk: findings from a prospective cohort study. Eur J Cancer Prev. 2021;30(3):275–81. doi: 10.1097/ CEJ.0000000000000660 26. A Brief Overview of the Diagnosis and Treatment of Cobalamin (B12) Deficiency Bruce H R Wolffenbuttel et al. Food Nutr Bull. 2024 Jun. 27. Noor, J.J. et al. (2025) 'Modulatory effects of Gingerol in cancer cell growth through activation and suppression of signal pathways in Cancer Cell Growth Systemic Review', Journal of Pharmacy and Bioallied Sciences, 16(Suppl 5). doi:10.4103/ jpbs.jpbs_1001_24.