Formulation and Evaluation of Fast Dissolving Tablets of Telmisartan Using Natural excipients: A Comprehensive Review

Hypertension is a chronic cardiovascular condition affecting a large proportion of the global population, leading to increased morbidity and mortality. Telmisartan, a selective angiotensin II receptor blocker, is frequently prescribed for its potent antihypertensive effects. However, conventional oral formulations of Telmisartan face challenges such as poor water solubility, slow dissolution rate, and delayed onset of action, which can negatively impact therapeutic efficacy and patient adherence. Fast dissolving tablets (FDTs) have emerged as a promising dosage form to address these limitations, providing rapid disintegration and immediate drug release without the need for water. The incorporation of natural superdisintegrants, derived from plant-based polymers such as guar gum, sodium alginate, and chitosan, has shown significant potential in enhancing disintegration and dissolution rates while offering advantages such as biocompatibility, biodegradability, and cost-effectiveness. This review provides a comprehensive analysis of Telmisartan FDTs, detailing natural excipient applications, formulation strategies, evaluation techniques, and stability considerations. The paper also highlights research gaps and future opportunities for developing more effective, patient-friendly, and sustainable oral drug delivery systems.