VUIIS-3T-FunctionalContrasts: 3T resting-state, visual, motor, and sensory fMRI with T1w and diffusion MRI

VUIIS-3T-FunctionalContrasts is a subject-organized multimodal MRI dataset associated with the study “Whole-brain, gray, and white matter time-locked functional signal changes with simple tasks and model-free analysis” (Schilling et al., PNAS 2023, 120(42):e2219666120). The release contains three-digit subject folders (001-018) with structural T1-weighted MRI, diffusion MRI (dwi.nii, dwi.bval, dwi.bvec), and up to six BOLD fMRI runs acquired on a 3T Philips Achieva CRX scanner at Vanderbilt University Institute of Imaging Science: resting state, visual stimulation, left/right motor task, and left/right sensory stimulation. Functional MRI was acquired with TR = 3 s, TE = 45 ms, 43 axial slices, 3 mm thickness, and 145 volumes per run. Task runs used a 30 s ON / 30 s OFF block design with five initial baseline volumes and seven repeated cycles; resting-state runs have the same duration.

In addition to primary images, the dataset includes derived files that document preprocessing and support downstream analysis: SPM slice-time corrected (a_*) and realigned/resliced (ra_*) fMRI volumes, FSL epi_reg EPI-to-structural registration outputs, T1-space functional images (ra_*_2t1.nii.gz). (note these have been removed due to upload size restricted, but can be made by applying transforms to data), FreeSurfer structural derivatives, dcm2niix NIfTI conversions of raw data, and TractSeg white-matter derivatives including tractography, streamline-density maps, and label maps in native and T1 space. Not all subjects contain every functional contrast. The associated manuscript analyzed a subset of 15 subjects, with 12 runs available for each BOLD contrast.