Seq2Bio: A Colab‑based tool for protein‑centric biological context retrieval

Seq2Bio is a comprehensive Google Colab notebook that transforms a protein sequence into a rich biological report. It integrates multiple public databases (NCBI BLAST, NCBI Taxonomy, iNaturalist, GBIF, PubMed) and tools (Clustal Omega, AlphaFold DB, ColabFold) to provide:

• BLAST homology search (≥70% identity)
• Taxonomic lineage
• Organism images and common names
• Interactive geographic map with hover tooltips (species, common name, image, location)
• Relevant PubMed publications (toxin/venom focused, but customisable)
• Multiple sequence alignment and phylogenetic tree (Newick format)
• Protein structure retrieval from AlphaFold DB or prediction via ColabFold, with confidence plots (pLDDT, PAE) and Ramachandran plots
• Downloadable ZIP archive of all results
• Email notification upon completion