Published March 13, 2026 | Version 1.0
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rémigén+ ® as an alginate-based hydrogel matrix with ionic components to support regenerative processes in Chronic Diabetic Wounds

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Description

Abstract
Chronic diabetic wounds cause substantial disability and, in severe cases, death. The wound microenvironment is dynamic, and its pH and ionic composition critically influence healing. Abnormal pH, ion levels, and ion-channel function may contribute to impaired healing. This review summarizes how pH and ions - Ca²⁺, Na⁺, K⁺ and Mg²⁺ - affect wound healing and surveys rémigén+ as an alginate-based hydrogel matrix with ionic components. The rémigén+ composition implies a synergy between the hydrating, gel-forming function of alginate and the buffering/ionic regulation provided by the phosphate group and cations. This review draws on established scientific data on alginate matrices, ionic regulation, and pH regulation in skin and wounds, as well as related studies on the effects of Ca²⁺, Mg²⁺, Na⁺, K⁺ and phosphates on skin and wound healing. The aim of the review is to connect known biochemical and physiological principles with hypotheses about how rémigén+ influences skin tissue and what evidence in the literature supports these hypotheses.

Keywords: Chronic diabetic wounds; pH; ions; ionic environment; wound healing; review; rémigén+; calcium (Ca2+); sodium (Na+); potassium (K+); magnesium (Mg2+).
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Hesh tags / Heshtags
#rémigénPlus #ChronicDiabeticWounds #WoundHealing #AlginateMatrix #HydrogelTechnology #IonicEnvironment #RegenerativeProcesses #SkinMicroenvironment #MedicalBiotechnology #HealthCareSolutions #ScienceAndResearch #AdvancedWoundTreatment #ScientificReview #InnovationsInMedicine #Biomaterials #IonRegulation #PhBalance #CellularFunction #HealingProcess #HydratingEffect #TissueReconstruction #MineralSupport #ions #Ca #Mg #Na #K #SkinRegeneration #pH #sodium #potassium #calcium #magnesium
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Title tag
Healing Chronic Diabetic Wounds: Exploring rémigén+®'s Innovative Approach
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Description tag
An in-depth review exploring how rémigén+®, an alginate-based hydrogel matrix, improves chronic diabetic wound healing by optimizing pH and ionic balance.
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Keywords tag
chronic diabetic wounds, rémigén+, alginate hydrogel, wound healing, pH regulation, ionic environment, calcium (Ca²⁺), sodium (Na⁺), potassium (K⁺), magnesium (Mg²⁺), skin regeneration
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Dates

Copyrighted
2026-03-13

References

  • 1. Liu S, Zhang Q, Yu J, et al. Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing. Adv Healthc Mater. 2020;9(11):e2000198. doi: 10.1002/adhm.202000198 [DOI] [PubMed] [Google Scholar]
  • 2. Shi M, Du Z, Qi Y, et al. Wound microenvironment-responsive glucose consumption and hydrogen peroxide generation synergistic with azithromycin for diabetic wounds healing. Theranostics. 2022;12(6):2658-2673. doi: 10.7150/thno.64244 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3. Wang PH, Huang BS, Horng HC, Yeh CC, Chen YJ. Wound healing. J Chin Med Assoc. 2018;81(2):94-101. doi: 10.1016/j.jcma.2017.11.002 [DOI] [PubMed] [Google Scholar]
  • 4. Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biol. 2020;10(9):200223. doi: 10.1098/rsob.200223 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5. Bai Q, Han K, Dong K, et al. Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing. Int j Nanomed. 2020;Volume 15(15):9717-9743. doi: 10.2147/IJN.S276001 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6. Deng H, Li B, Shen Q, et al. Mechanisms of diabetic foot ulceration: a review. J Diab. 2023;15(4):299-312. doi: 10.1111/1753-0407.13372 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7. Choudhury H, Pandey M, Lim YQ, et al. Silver nanoparticles: advanced and promising technology in diabetic wound therapy. Materials science & engineering. Mat Biol Appli. 2020;112(110925). [DOI] [PubMed] [Google Scholar]
  • 8. Prabhakar PK, Singh K, Kabra D, Gupta J. Natural SIRT1 modifiers as promising therapeutic agents for improving diabetic wound healing. Phytomedicine. Inter j Phytothera Phytopharm. 2020;76:153252. doi: 10.1016/j.phymed.2020.153252 [DOI] [PubMed] [Google Scholar]
  • 9. Zhao Y, Zhao Y, Xu B, Liu H, Chang Q. Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics. J Tissue Engin. 2024;15. doi: 10.1177/20417314241253290 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10. Cheng B, Fu XB. Microenvironment control is the only way to achieve perfect wound repair. Zhonghua Shao Shang Za Zhi. 2020;36(11):1003-1008. doi: 10.3760/cma.j.cn501120-20201009-00429 [DOI] [PubMed] [Google Scholar]
  • 11. Choudhary V, Olala LO, Kagha K, et al. Regulation of the Glycerol Transporter, Aquaporin-3, by Histone Deacetylase-3 and p53 in Keratinocytes. J Invest Dermatol 2017;137(9):1935-1944; doi: 10.1016/j.jid.2017.04.031 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12. Kolbe L, Kligman AM, Schreiner V, et al. Corticosteroid-induced atrophy and barrier impairment measured by non-invasive methods in human skin. Skin Res Technol 2001;7(2):73-77; doi: 10.1034/j.1600-0846.2001.70203.x [DOI] [PubMed] [Google Scholar]
  • 13. Chen L, Jiang P, Li J, et al. Periplocin promotes wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase. Phytomedicine 2019;57:72-83; doi: 10.1016/j.phymed.2018.12.015 [DOI] [PubMed] [Google Scholar]
  • 14. Nuccitelli R, Nuccitelli P, Ramlatchan S, et al. Imaging the electric field associated with mouse and human skin wounds. Wound Repair Regen 2008;16(3):432-441; doi: 10.1111/j.1524-475X.2008.00389.x [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15. Ohman H, Vahlquist A. The pH gradient over the stratum corneum differs in X-linked recessive and autosomal dominant ichthyosis: a clue to the molecular origin of the "acid skin mantle"? J Invest Dermatol 1998;111(4):674-677; doi: 10.1046/j.1523-1747.1998.00356.x [DOI] [PubMed] [Google Scholar]
  • 16. Russo B, Brembilla NC, Chizzolini C. Interplay between keratinocytes and fibroblasts: A systematic review providing a new angle for understanding skin fibrotic disorders. Front Immunol 2020;11:648; doi: 10.3389/fimmu.2020.00648 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17. Maintaining and Restoring Gradients of Ions in the Epidermis: The Role of Ion and Water Channels in Acute Cutaneous Wound Healing Kevin Mai 1,*, Emanual Maverakis 2, Jung Li 3, Min Zhao 2,4 PMCID: PMC10615091 PMID: 37051706
  • 18. Zhao M. Electrical fields in wound healing-An overriding signal that directs cell migration. Semin Cell Dev Biol. 2009;20(6):674-682. doi: 10.1016/j.semcdb.2008.12.009 [DOI] [PubMed] [Google Scholar]
  • 19.Tran V, Zhang X, Cao L, et al. Synchronization modulation increases transepithelial potentials in MDCK monolayers through Na/K pumps. PLoS One. 2013;8(4):e61509. doi: 10.1371/journal.pone.0061509 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20. Implications of pH and Ionic Environment in Chronic Diabetic Wounds: An Overlooked Perspective Jing Guo 1, Yi Cao 1, Qing-Yuan Wu 2, Yi-Mai Zhou 3, Yuan-Hao Cao 3, Lu-Sha Cen 4,✉ PMCID: PMC11590674 PMID: 39600531
  • 21. Berridge MJ, Bootman MD, Lipp P. Calcium-a life and death signal. Nature. 1998;395:6703):645-8. doi: 10.1038/27094 [DOI] [PubMed] [Google Scholar]
  • 22. Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art Mohammad A S Abourehab 1,2,*, Rahul R Rajendran 3, Anshul Singh 4, Sheersha Pramanik 5,*, Prachi Shrivastav 6,7, Mohammad Javed Ansari 8, Ravi Manne 9, Larissa Souza Amaral 10, A Deepak 11 PMCID: PMC9409034 PMID: 36012297
  • 23. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999;341(10):738-46; doi: 10.1056/nejm199909023411006 [DOI] [PubMed] [Google Scholar]
  • 24. Zhang W, Bei M. Kcnh2 and Kcnj8 interactively regulate skin wound healing and regeneration. Wound Repair Regen 2015;23(6):797-806; doi: 10.1111/wrr.12347 [DOI] [PubMed] [Google Scholar]
  • 25. Haverkampf S, Heider J, Weiß KT, et al. NHE1 expression at wound margins increases time-dependently during physiological healing. Exp Dermatol 2017;26(2):124-126; doi: 10.1111/exd.13097 [DOI] [PubMed] [Google Scholar]
  • 26. The Electrical Response to Injury: Molecular Mechanisms and Wound Healing Brian Reid 1,*, Min Zhao 1 PMCID: PMC3928722 PMID: 24761358
  • 27. From Wound Dressing to Tissue Regeneration: Bilayer Medicated Patches for Personalized Treatments of Chronic Wounds Sara Bernardoni †, Elisabetta Campodoni †,*, Gaia Vicinelli †, Mohamed Saqawa †,‡, Francesca Bonvicini §, Laura Pulze ∥, Nicoló Baranzini ∥, Giorgia Costantini ∥, Monica Montesi †, Giovanna Angela Gentilomi §,⊥, Annalisa Grimaldi ∥, Monica Sandri †,* PMCID: PMC12186226 PMID: 40469021