Isotopic Modulation of the Background Field D in Alzheimer's Disease: A Geometric Hypothesis for Amyloid-β Aggregation via Deuterium Accumulation

This paper proposes a novel biophysical mech-

anism for Alzheimer’s disease based on the Non-

Equilibrium Unified Theory (NEUT). We hypoth-

esize that the accumulation of deuterium (2H) in

the brain increases the background complexity field

D, shifting the geometric equilibrium radius req of

Amyloid-β (Aβ) proteins. Numerical simulations

demonstrate that when D exceeds a critical thresh-

old (D ≈ 1.5), the repulsive barrier of Aβ monomers

is compromised, leading to a ”geometric trap” where

neighboring molecules fall into an irreversible attrac-

tive phase. This framework identifies the local iso-

topic balance as a primary determinant of the indi-

vidual variance in neurodegeneration progression.