Published March 9, 2026 | Version v2.7.5
Software Open

CARLISLE: Cut And Run anaLysIS pipeLinE

  • 1. Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA

Description

CARLISLE 2.7.5

New Features

  • ROSE containerization: Containerized the ROSE workflow, added a dedicated prep script, and simplified dependencies by removing annotation-folder/refseq coupling for supported genomes (hg19, hg38, mm10). (@kopardev)
  • GO enrichment workflow split: Separated GO enrichment table generation from dotplot generation to improve rerun behavior and failure isolation. (@kopardev)

Improvements

  • ROSE output streamlining: Reduced ROSE outputs to only required deliverables and adjusted cluster resource requests accordingly. (@kopardev)
  • GO enrichment execution hardening: Improved GO enrichment and dotplot logging and scheduling defaults for cluster execution. (#210, #211, #212, #213, @kopardev)

Bug Fixes

  • GO enrichment robustness: Handle empty BED/TSV inputs without hard failure and improve fallback checks in dotplot generation. (#212, @kopardev)
  • Dotplot label handling: Fix duplicate wrapped enrichment labels in GO dotplot output. (@kopardev)
  • ROSE empty-input handling: Prevent hard failures when ROSE prep receives empty peak inputs. (@kopardev)

Notes

If you use CARLISLE, please cite it as below.

Files

CCBR/CARLISLE-v2.7.5.zip

Files (314.8 MB)

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Additional details

Related works

Is supplement to
Software: https://github.com/CCBR/CARLISLE/tree/v2.7.5 (URL)

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