TrialMCP Pack: MCP Servers for Physical AI Oncology Clinical Trial Systems

Summary

This release adds three comprehensive 10-page research papers presenting TrialMCP from complementary perspectives: Clinical Operations, Regulatory/Quality/Compliance, and Healthcare Interoperability/Standards. All three papers are published under DOI 10.5281/zenodo.18870961 with full LaTeX source files. The release includes a new /papers directory with individual and combined PDFs, LaTeX source archives, and updated repository documentation.

Features

• Paper A -- Clinical Operations: Addresses trial sponsors, CRO leadership, and site networks with focus on workflow sequences, deployment topology for federated multi-site trials, integration project reduction analysis (69% fewer projects at scale), and three-phase adoption pathway.
• Paper B -- Regulatory: Addresses QA/CSV teams, auditors, and compliance officers with compliance-first architecture mapping to 21 CFR Part 11, ICH-GCP E6(R2), and HIPAA Safe Harbor. Includes complete permission matrix, error taxonomy, and 39-test validation evidence.
• Paper C -- Interoperability: Addresses health IT architects and standards contributors with MCP as agent-tool interface composing with FHIR R4 and DICOM. Covers tool surface area (23 tools, 5 servers), security gate architecture, and production integration pathways (HAPI FHIR, Orthanc, dcm4chee).
• Combined PDF: All three papers merged in order (A, B, C) with original page numbering preserved (1-10, 1-10, 1-10).
• LaTeX Source Archives: Each paper includes a zip file with .tex, .bib, .sty, and README files with distinguishable filenames.
• Papers README: Directory-level documentation with paper overview, citation, and structure.
• Updated documentation: prompts.md with v0.3.0 build prompt, changelog.md with v0.3.0 entry, releases.md with v0.3.0 notes.

Contributors

@kevinkawchak @claude @openai

Notes

• All three papers share DOI 10.5281/zenodo.18870961 and are licensed under CC BY 4.0.
• Papers are built from the v0.2.0 codebase (5 MCP servers, 23 tools, 39 tests) with no runtime code changes.
• Each paper is self-contained with its own abstract, table of contents, introduction, methods, results, discussion, limitations, conclusion, references, acknowledgments, ethical disclosures, rights/permissions, and citation section.
• LaTeX build requires texlive-latex-base, texlive-latex-extra, texlive-fonts-recommended, and texlive-science.
• Python 3.10+ compatible. No new runtime dependencies.