Published March 4, 2026 | Version v1
Dataset Open

THE ROLE OF INFLAMMATORY MARKERS IN THE EARLY DIAGNOSIS OF SEPSIS

Description

Sepsis is a life-threatening condition resulting from the body's extreme response to infection. Early diagnosis is crucial to reduce morbidity and mortality. Inflammatory markers, such as C-reactive protein (CRP), procalcitonin (PCT), and interleukins, play a vital role in the early identification and management of sepsis. This study investigates the diagnostic value of these biomarkers in patients with suspected sepsis in intensive care units (ICUs).

Files

36-37.pdf

Files (279.1 kB)

Name Size
md5:0e592f4d2c0acafabf557e4c5bcd4bae
279.1 kB Preview Download

Additional details

References

  • 1.Angus, D. C., & van der Poll, T. (2013). Severe sepsis and septic shock. New England Journal of Medicine, 369(9), 840–851. https://doi.org/10.1056/NEJMra1208623
  • 2.Becker, K. L., Nylen, E. S., White, J. C., Müller, B., & Snider, R. H. (2004). Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. Journal of Clinical Endocrinology & Metabolism, 89(4), 1512–1525.
  • 3.Pierrakos, C., & Vincent, J. L. (2010). Sepsis biomarkers: a review. Critical Care, 14(1), R15. https://doi.org/10.1186/cc8872
  • 4.Wacker, C., Prkno, A., Brunkhorst, F. M., & Schlattmann, P. (2013). Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. The Lancet Infectious Diseases, 13(5), 426–435.
  • 5.Tan, M., Lu, Y., Jiang, H., & Zhang, L. (2014). The diagnostic accuracy of procalcitonin and C-reactive protein for sepsis: A systematic review and meta-analysis. Journal of Cellular Biochemistry, 115(5), 982–986.
  • 6.Schuetz, P., Albrich, W., & Mueller, B. (2011). Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future. BMC Medicine, 9, 107. https://doi.org/10.1186/1741-7015-9-107
  • 7.Gogos, C. A., Drosou, E., Bassaris, H. P., & Skoutelis, A. (2000). Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. Journal of Infectious Diseases, 181(1), 176–180
  • 8.Meisner, M. (2014). Update on procalcitonin measurements. Annals of Laboratory Medicine, 34(4), 263–273.
  • 9.Póvoa, P. (2002). C-reactive protein: a valuable marker of sepsis. Intensive Care Medicine, 28(3), 235–243.
  • 10.Dellinger, R. P., Levy, M. M., Rhodes, A., et al. (2013). Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Medicine, 39(2), 165–228.